Selected article for: "cell type and cytokine expression"
Author: Morales, Lucía; Oliveros, Juan Carlos; Fernandez-Delgado, Raúl; tenOever, Benjamin Robert; Enjuanes, Luis; Sola, Isabel
Title: SARS-CoV-Encoded Small RNAs Contribute to Infection-Associated Lung Pathology
  • Cord-id: 9y7bgd80
  • Document date: 2017_3_1
    • ID: 9y7bgd80
    Snippet: Severe acute respiratory syndrome coronavirus (SARS-CoV) causes lethal disease in humans, which is characterized by exacerbated inflammatory response and extensive lung pathology. To address the relevance of small non-coding RNAs in SARS-CoV pathology, we deep sequenced RNAs from the lungs of infected mice and discovered three 18–22 nt small viral RNAs (svRNAs). The three svRNAs were derived from the nsp3 (svRNA-nsp3.1 and -nsp3.2) and N (svRNA-N) genomic regions of SARS-CoV. Biogenesis of CoV
    Document: Severe acute respiratory syndrome coronavirus (SARS-CoV) causes lethal disease in humans, which is characterized by exacerbated inflammatory response and extensive lung pathology. To address the relevance of small non-coding RNAs in SARS-CoV pathology, we deep sequenced RNAs from the lungs of infected mice and discovered three 18–22 nt small viral RNAs (svRNAs). The three svRNAs were derived from the nsp3 (svRNA-nsp3.1 and -nsp3.2) and N (svRNA-N) genomic regions of SARS-CoV. Biogenesis of CoV svRNAs was RNase III, cell type, and host species independent, but it was dependent on the extent of viral replication. Antagomir-mediated inhibition of svRNA-N significantly reduced in vivo lung pathology and pro-inflammatory cytokine expression. Taken together, these data indicate that svRNAs contribute to SARS-CoV pathogenesis and highlight the potential of svRNA-N antagomirs as antivirals.

    Search related documents:
    Co phrase search for related documents
    • absence presence and activity confirm: 1, 2
    • absence presence and acute ards respiratory distress syndrome: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11
    • absence presence and acute sars cov respiratory syndrome coronavirus: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25
    • acidic domain and action mechanism: 1
    • acidic domain and acute sars cov respiratory syndrome coronavirus: 1, 2
    • acidic domain and adp domain: 1, 2
    • action different mechanism and acute ards respiratory distress syndrome: 1
    • action different mechanism and acute sars cov respiratory syndrome coronavirus: 1, 2
    • action mechanism and acute ards respiratory distress syndrome: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17
    • action mechanism and acute sars cov respiratory syndrome coronavirus: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25
    • action mechanism and adp domain: 1
    • activity confirm and acute ards respiratory distress syndrome: 1
    • activity confirm and acute sars cov respiratory syndrome coronavirus: 1, 2, 3, 4
    • activity confirm and adp domain: 1
    • acute sars cov respiratory syndrome coronavirus and adjacent section: 1
    • acute sars cov respiratory syndrome coronavirus and adp domain: 1, 2, 3, 4, 5, 6
    • acute sars cov respiratory syndrome coronavirus and lna nucleic acid: 1, 2