Author: Tong, Pei; Gautam, Avneesh; Windsor, Ian; Travers, Meghan; Chen, Yuezhou; Garcia, Nicholas; Whiteman, Noah B.; McKay, Lindsay G.A.; Lelis, Felipe J.N.; Habibi, Shaghayegh; Cai, Yongfei; Rennick, Linda J.; Duprex, W. Paul; McCarthy, Kevin R.; Lavine, Christy L.; Zuo, Teng; Lin, Junrui; Zuiani, Adam; Feldman, Jared; MacDonald, Elizabeth A.; Hauser, Blake M.; Griffths, Anthony; Seaman, Michael S.; Schmidt, Aaron G.; Chen, Bing; Neuberg, Donna; Bajic, Goran; Harrison, Stephen C; Wesemann, Duane R.
Title: Memory B cell repertoire for recognition of evolving SARS-CoV-2 spike Cord-id: 9nmnv4pd Document date: 2021_3_10
ID: 9nmnv4pd
Snippet: Memory B cell reserves can generate protective antibodies against repeated SARS-CoV-2 infections, but with an unknown reach from original infection to antigenically drifted variants. We charted memory B cell receptor-encoded monoclonal antibodies (mAbs) from 19 COVID-19 convalescent subjects against SARS-CoV-2 spike (S) and found 7 major mAb competition groups against epitopes recurrently targeted across individuals. Inclusion of published and newly determined structures of mAb-S complexes ident
Document: Memory B cell reserves can generate protective antibodies against repeated SARS-CoV-2 infections, but with an unknown reach from original infection to antigenically drifted variants. We charted memory B cell receptor-encoded monoclonal antibodies (mAbs) from 19 COVID-19 convalescent subjects against SARS-CoV-2 spike (S) and found 7 major mAb competition groups against epitopes recurrently targeted across individuals. Inclusion of published and newly determined structures of mAb-S complexes identified corresponding epitopic regions. Group assignment correlated with cross-CoV-reactivity breadth, neutralization potency, and convergent antibody signatures. mAbs that competed for binding the original S isolate bound differentially to S variants, suggesting the protective importance of otherwise-redundant recognition. The results furnish a global atlas of the S-specific memory B cell repertoire and illustrate properties conferring robustness against emerging SARS-CoV-2 variants.
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