Author: Daniel Bean; Zeljko Kraljevic; Thomas Searle; Rebecca Bendayan; Andrew Pickles; Amos Folarin; Lukasz Roguski; Kawsar Noor; Anthony Shek; Kevin o'gallagher; Rosita Zakeri; Ajay Shah; James Teo; Richard JB Dobson
Title: Treatment with ACE-inhibitors is associated with less severe disease with SARS-Covid-19 infection in a multi-site UK acute Hospital Trust Document date: 2020_4_11
ID: 60wcvkbn_16
Snippet: We assessed the robustness to unmeasured confounders of the fully adjusted estimate of ACEi protective effect using the e-value approach. 18 An e-value of 3.32 for the point estimate indicated that it was robust to plausible residual confounding that might explain away the estimate. However, the e-value of 1.58 for the upper confidence of 0.75 showed that in the presence of residual confounding of a level often considered plausible, this study co.....
Document: We assessed the robustness to unmeasured confounders of the fully adjusted estimate of ACEi protective effect using the e-value approach. 18 An e-value of 3.32 for the point estimate indicated that it was robust to plausible residual confounding that might explain away the estimate. However, the e-value of 1.58 for the upper confidence of 0.75 showed that in the presence of residual confounding of a level often considered plausible, this study could not fully exclude the possibility of small harmful effects.
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