Author: Hazel Stewart; Katherine Brown; Adam M. Dinan; Nerea Irigoyen; Eric J. Snijder; Andrew E. Firth
Title: The transcriptional and translational landscape of equine torovirus Document date: 2018_4_7
ID: mozfm5ds_60
Snippet: Despite the relatively large size of the U2 protein (~30 kDa), after extensive database 511 searches no structural homologs were identified. By comparison, the U1 protein is 512 small (~10 kDa), highly basic (pI = 10.4) and possesses many of the predicted features 513 of a double-spanning transmembrane protein, including two hydrophobic stretches 514 separated by a 'hinge' and a predicted coiled-coil tertiary topology. Based on 515 structural sim.....
Document: Despite the relatively large size of the U2 protein (~30 kDa), after extensive database 511 searches no structural homologs were identified. By comparison, the U1 protein is 512 small (~10 kDa), highly basic (pI = 10.4) and possesses many of the predicted features 513 of a double-spanning transmembrane protein, including two hydrophobic stretches 514 separated by a 'hinge' and a predicted coiled-coil tertiary topology. Based on 515 structural similarity to known proteins, one potential function might be a virally 516 encoded ion channel (viroporin) embedded in either intracellular or plasma 517 membranes. It is possible that U1 plays a similar role in toroviruses to that of the 518 coronaviral and arteriviral E proteins, which have no known toroviral homologue. 519
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