Selected article for: "comparative genomic and genomic analysis"
Author: Hazel Stewart; Katherine Brown; Adam M. Dinan; Nerea Irigoyen; Eric J. Snijder; Andrew E. Firth
Title: The transcriptional and translational landscape of equine torovirus
  • Document date: 2018_4_7
    • ID: mozfm5ds_62
    Snippet: Alternatively viroporin activity may be mediated by a small, basic double-525 transmembrane protein, the ORF of which is embedded within the EToV N gene in 526 the +1 frame (with respect to N). An analogous "N+1" protein has been identified in 527 some group II coronaviruses and is postulated to play a structural role, however it is 528 not essential for replication (49, 50). Neither our ribosome profiling nor comparative 529 genomic analysis pro.....
    Document: Alternatively viroporin activity may be mediated by a small, basic double-525 transmembrane protein, the ORF of which is embedded within the EToV N gene in 526 the +1 frame (with respect to N). An analogous "N+1" protein has been identified in 527 some group II coronaviruses and is postulated to play a structural role, however it is 528 not essential for replication (49, 50). Neither our ribosome profiling nor comparative 529 genomic analysis provides evidence that this ORF is utilised in toroviruses. We did 530 not observe ribosomes translating in this frame in either the initial dataset or the 531 drug-treated samples (although Ribo-seq may not always detect poorly translated 532 overlapping genes); further, the ORF is not preserved in all torovirus genomes. 533

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