Author: Breton, Gaëlle; Mendoza, Pilar; Hagglof, Thomas; Oliveira, Thiago Y.; Schaefer-Babajew, Dennis; Gaebler, Christian; Turroja, Martina; Hurley, Arlene; Caskey, Marina; Nussenzweig, Michel C.
Title: Persistent Cellular Immunity to SARS-CoV-2 Infection Cord-id: 8ndxxvl2 Document date: 2020_12_9
ID: 8ndxxvl2
Snippet: SARS-CoV-2 is responsible for an ongoing pandemic that affected millions of individuals around the globe. To gain further understanding of the immune response in recovered individuals we measured T cell responses in paired samples obtained an average of 1.3 and 6.1 months after infection from 41 individuals. The data indicate that recovered individuals show persistent polyfunctional SARS-CoV-2 antigen specific memory that could contribute to rapid recall responses. In addition, recovered individ
Document: SARS-CoV-2 is responsible for an ongoing pandemic that affected millions of individuals around the globe. To gain further understanding of the immune response in recovered individuals we measured T cell responses in paired samples obtained an average of 1.3 and 6.1 months after infection from 41 individuals. The data indicate that recovered individuals show persistent polyfunctional SARS-CoV-2 antigen specific memory that could contribute to rapid recall responses. In addition, recovered individuals show enduring immune alterations in relative numbers of CD4(+) and CD8(+) T cells, expression of activation/exhaustion markers, and cell division.
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