Selected article for: "host response and infection host response"
Author: Xiaoyang Ji; Chunming Zhang; Yubo Zhai; Zhonghai Zhang; Chunli Zhang; Yiqing Xue; Guangming Tan; Gang Niu
Title: TWIRLS, an automated topic-wise inference method based on massive literature, suggests a possible mechanism via ACE2 for the pathological changes in the human host after coronavirus infection
  • Document date: 2020_3_2
    • ID: eaglecq7_21
    Snippet: The copyright holder for this preprint (which was not peer-reviewed) is the . https://doi.org/10.1101/2020.02.27.967588 doi: bioRxiv preprint studies (average 0.03% in the control test of random samplings, p <1.5676e-61). The IFITMs family plays crucial roles in the induction of interferons during viral infections. Under the action of interferon, IFITMs disrupts intracellular cholesterol homeostasis and prevents the virus from entering the host c.....
    Document: The copyright holder for this preprint (which was not peer-reviewed) is the . https://doi.org/10.1101/2020.02.27.967588 doi: bioRxiv preprint studies (average 0.03% in the control test of random samplings, p <1.5676e-61). The IFITMs family plays crucial roles in the induction of interferons during viral infections. Under the action of interferon, IFITMs disrupts intracellular cholesterol homeostasis and prevents the virus from entering the host cell [11] . However, TWIRLS did not directly associate IFITMs with any category, so we needed to provide more information so that TWIRLS can determine which part of these genes might be involved in the coronavirus infection and host body response.

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