Author: Yan Li; Jinyong Zhang; Ning Wang; Haibo Li; Yun Shi; Gang Guo; Kaiyun Liu; Hao Zeng; Quanming Zou
Title: Therapeutic Drugs Targeting 2019-nCoV Main Protease by High-Throughput Screening Document date: 2020_1_29
ID: iu2ziccm_2
Snippet: The discovery and clinical application of specific drugs against 2019-nCoV is an effective means to alleviate the current epidemic. However, there are no clinically effective drugs for this virus for the moment. Although 2019-nCoV is significantly different from SARS-CoV, which breakout in Beijing 17 years before [3] , the sequence identity between themis as high as 79.5%. Further sequence alignment revealed that the similarity of the sequence of.....
Document: The discovery and clinical application of specific drugs against 2019-nCoV is an effective means to alleviate the current epidemic. However, there are no clinically effective drugs for this virus for the moment. Although 2019-nCoV is significantly different from SARS-CoV, which breakout in Beijing 17 years before [3] , the sequence identity between themis as high as 79.5%. Further sequence alignment revealed that the similarity of the sequence of the main protease between 2019-nCoV and SARS-CoV is up to 96.1%. Previous study demonstrated that the main protease of SARS-CoV is essential for the life cycle of the virus, and is considered to be an attractive target for drug development [4] . Thus, this protein could be used as a homologous target to screening drugs that inhibiting the replication and proliferation of 2019-nCoV.
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