Selected article for: "drug resistance mutation and new drug"

Author: Yang, Zheng Rong; Young, Natasha
Title: Bio-kernel Self-organizing Map for HIV Drug Resistance Classification
  • Cord-id: 8mjrrlni
  • Document date: 2005_1_1
  • ID: 8mjrrlni
    Snippet: Kernel self-organizing map has been recently studied by Fyfe and his colleagues [1]. This paper investigates the use of a novel bio-kernel function for the kernel self-organizing map. For verification, the application of the proposed new kernel self-organizing map to HIV drug resistance classification using mutation patterns in protease sequences is presented. The original self-organizing map together with the distributed encoding method was compared. It has been found that the use of the kernel
    Document: Kernel self-organizing map has been recently studied by Fyfe and his colleagues [1]. This paper investigates the use of a novel bio-kernel function for the kernel self-organizing map. For verification, the application of the proposed new kernel self-organizing map to HIV drug resistance classification using mutation patterns in protease sequences is presented. The original self-organizing map together with the distributed encoding method was compared. It has been found that the use of the kernel self-organizing map with the novel bio-kernel function leads to better classification and faster convergence rate ...

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