Author: Rohan Maddamsetti; Daniel T. Johnson; Stephanie J. Spielman; Katherine L. Petrie; Debora S. Marks; Justin R. Meyer
Title: Viral gain-of-function experiments uncover residues under diversifying selection in nature Document date: 2018_1_3
ID: gqhlw20n_1
Snippet: populations. Indeed, some researchers have called for the suspension of virus gain-of-function laboratory experiments 13 on the grounds that they would tell us little about real-world viral evolution at the risk of constructing viral strains that are pandemic to new hosts. Here, we use a harmless virus, bacteriophage lï¬, to demonstrate how gain-of-function experiments can identify mutations that mimic those that occur in nature: we find that tw.....
Document: populations. Indeed, some researchers have called for the suspension of virus gain-of-function laboratory experiments 13 on the grounds that they would tell us little about real-world viral evolution at the risk of constructing viral strains that are pandemic to new hosts. Here, we use a harmless virus, bacteriophage lï¬, to demonstrate how gain-of-function experiments can identify mutations that mimic those that occur in nature: we find that two amino acid residues that are critical for gain of function in the laboratory recurrently evolve in nature.
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