Author: Rohan Maddamsetti; Daniel T. Johnson; Stephanie J. Spielman; Katherine L. Petrie; Debora S. Marks; Justin R. Meyer
Title: Viral gain-of-function experiments uncover residues under diversifying selection in nature Document date: 2018_1_3
ID: gqhlw20n_6
Snippet: We then asked whether natural J sequences reflected the host-shift evolutionary dynamics seen in our gain-of-function experiments. We collected and aligned full-length homologous J protein sequences from UniRef100 16 (1,207 highly similar sequences). Most sequences were prophage uncovered in the genomes of their Enterobacteriaceae hosts, including bacterial genera Escherichia, Salmonella, Citrobacter, Edwardsiella, and even Cronobacter......
Document: We then asked whether natural J sequences reflected the host-shift evolutionary dynamics seen in our gain-of-function experiments. We collected and aligned full-length homologous J protein sequences from UniRef100 16 (1,207 highly similar sequences). Most sequences were prophage uncovered in the genomes of their Enterobacteriaceae hosts, including bacterial genera Escherichia, Salmonella, Citrobacter, Edwardsiella, and even Cronobacter.
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