Selected article for: "blood mononuclear and peripheral blood mononuclear"

Author: Daniela Weiskopf; Katharina S. Schmitz; Matthijs P. Raadsen; Alba Grifoni; Nisreen M.A. Okba; Henrik Endeman; Johannes P.C. van den Akker; Richard Molenkamp; Marion P.G. Koopmans; Eric C.M. van Gorp; Bart L. Haagmans; Rik L. de Swart; Alessandro Sette; Rory Dylan de Vries
Title: Phenotype of SARS-CoV-2-specific T-cells in COVID-19 patients with acute respiratory distress syndrome
  • Document date: 2020_4_18
  • ID: 97gme3pl_2
    Snippet: Despite the large numbers of cases and deaths, no information is available on the phenotype of SARS-CoV-2-specific T-cells. Here, we stimulated peripheral blood mononuclear cells (PBMC) from eight COVID-19 patients with ARDS, collected up to three weeks after admission to the intensive care unit (ICU), with MegaPools (MP) of overlapping or prediction-based peptides covering the SARS-CoV-2 proteome 7 . We detected SARS-CoV-2-specific CD4 + and CD8.....
    Document: Despite the large numbers of cases and deaths, no information is available on the phenotype of SARS-CoV-2-specific T-cells. Here, we stimulated peripheral blood mononuclear cells (PBMC) from eight COVID-19 patients with ARDS, collected up to three weeks after admission to the intensive care unit (ICU), with MegaPools (MP) of overlapping or prediction-based peptides covering the SARS-CoV-2 proteome 7 . We detected SARS-CoV-2-specific CD4 + and CD8 + T-cells in all COVID-19 patients, whereas peptide stimulation of healthy control PBMC samples collected before the outbreak showed no response. SARS-CoV-2-specific T-cells predominantly produced Th1 cytokines, although Th2 cytokines were also detected.

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