Author: Daniela Weiskopf; Katharina S. Schmitz; Matthijs P. Raadsen; Alba Grifoni; Nisreen M.A. Okba; Henrik Endeman; Johannes P.C. van den Akker; Richard Molenkamp; Marion P.G. Koopmans; Eric C.M. van Gorp; Bart L. Haagmans; Rik L. de Swart; Alessandro Sette; Rory Dylan de Vries
Title: Phenotype of SARS-CoV-2-specific T-cells in COVID-19 patients with acute respiratory distress syndrome Document date: 2020_4_18
ID: 97gme3pl_7
Snippet: They received antibiotics as a part of a treatment regime aimed at selective decontamination of the digestive tract. No antiviral or immunomodulatory drugs were used. All patients were at the ICU and included shortly after ICU admission; selfreported illness varied between 5 and 14 days before inclusion (Figure 1a CD4:CD8 ratios were increased in COVID-19 patients when compared to HC (6.2 ± 3.0 in COVID-19 vs 2.4 ± 1.0 in HC, p=0.0037, Figure 1.....
Document: They received antibiotics as a part of a treatment regime aimed at selective decontamination of the digestive tract. No antiviral or immunomodulatory drugs were used. All patients were at the ICU and included shortly after ICU admission; selfreported illness varied between 5 and 14 days before inclusion (Figure 1a CD4:CD8 ratios were increased in COVID-19 patients when compared to HC (6.2 ± 3.0 in COVID-19 vs 2.4 ± 1.0 in HC, p=0.0037, Figure 1c ). This may reflect migration of CD8 + T-cells to the respiratory tract. PBMC were stimulated with three different peptide MPs: MP_S, MP_CD4_R and two MP_CD8 pools. MP_S contained 221 overlapping peptides (15-mers overlapping by 10 amino acids) covering the entire surface glycoprotein (spike, S) and can stimulate both CD4 + and CD8 + T-cells. MP_CD4_R contained 246 HLA class II predicted All rights reserved. No reuse allowed without permission. the author/funder, who has granted medRxiv a license to display the preprint in perpetuity.
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