Author: T. Kuhn; T. Kaufmann; N.T. Doan; L.T. Westlye; J. Jones; R.A. Nunez; S.Y. Bookheimer; E.J. Singer; C.H. Hinkin; A.D. Thames
Title: An Augmented Aging Process in Brain White Matter in HIV Document date: 2018_2_14
ID: 8izuaesr_23
Snippet: Importantly, in our sample in which 11% of the HIV+ participants evidenced a detectable HIV RNA viral load, current CD4 and detectable viral load were not related to BAG. Conversely, highest lifetime HIV RNA viral load, which was not the current viral load for any participant, was related to BAG in the HIV+ group, even after controlling for factors such as HIV duration, pre-versus post-HAART diagnosis and medical comorbidities. Highest lifetime v.....
Document: Importantly, in our sample in which 11% of the HIV+ participants evidenced a detectable HIV RNA viral load, current CD4 and detectable viral load were not related to BAG. Conversely, highest lifetime HIV RNA viral load, which was not the current viral load for any participant, was related to BAG in the HIV+ group, even after controlling for factors such as HIV duration, pre-versus post-HAART diagnosis and medical comorbidities. Highest lifetime viral load also was not different between the younger and older HIV+ groups. Furthermore, older HIV+ participants who reported high plasma viral load had the greatest discrepancy between their estimated brain age and chronological age, suggesting that history of high viral burden contributes to accentuated brain aging.
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