Author: Antonio Gonçalves; Julie Bertrand; Ruian Ke; Emmanuelle Comets; Xavier de Lamballerie; Denis Malvy; Andrés Pizzorno; Olivier Terrier; Manuel Rosa Calatrava; France Mentré; Patrick Smith; Alan S Perelson; Jérémie Guedj
Title: Timing of antiviral treatment initiation is critical to reduce SARS-Cov-2 viral load Document date: 2020_4_7
ID: n6l2804j_22
Snippet: As predicted by viral kinetic modeling theory [2], we found that the impact of treatment on 166 peak viral load is inversely correlated with the time of treatment initiation. For a putative 167 treatment initiated at the time of infection, symptom onset, or 3 days post symptom onset, a 168 median efficacy of at least 60, 90 and 99% in reducing viral replication would be needed, 169 respectively, to generate more than 2 log of decline in the peak .....
Document: As predicted by viral kinetic modeling theory [2], we found that the impact of treatment on 166 peak viral load is inversely correlated with the time of treatment initiation. For a putative 167 treatment initiated at the time of infection, symptom onset, or 3 days post symptom onset, a 168 median efficacy of at least 60, 90 and 99% in reducing viral replication would be needed, 169 respectively, to generate more than 2 log of decline in the peak viral load (Fig. 1) . 170 author/funder, who has granted medRxiv a license to display the preprint in perpetuity.
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