Selected article for: "cleavage site and Spike protein"

Author: Dorothea Bestle; Miriam Ruth Heindl; Hannah Limburg; Thuy Van Lam van; Oliver Pilgram; Hong Moulton; David A. Stein; Kornelia Hardes; Markus Eickmann; Olga Dolnik; Cornelius Rohde; Stephan Becker; Hans-Dieter Klenk; Wolfgang Garten; Torsten Steinmetzer; Eva Böttcher-Friebertshäuser
Title: TMPRSS2 and furin are both essential for proteolytic activation and spread of SARS-CoV-2 in human airway epithelial cells and provide promising drug targets
  • Document date: 2020_4_15
  • ID: anedg12x_10
    Snippet: show that the R-R-A-R motif at the S1/S2 cleavage site of SARS-CoV-2 S is efficiently 168 cleaved by furin in vitro. 169 SARS-Cov-2 spike protein is cleaved by both furin and TMPRSS2 171.....
    Document: show that the R-R-A-R motif at the S1/S2 cleavage site of SARS-CoV-2 S is efficiently 168 cleaved by furin in vitro. 169 SARS-Cov-2 spike protein is cleaved by both furin and TMPRSS2 171

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