Author: Andreani, Julien; Le Bideau, Marion; Duflot, Isabelle; Jardot, Priscilla; Rolland, Clara; Boxberger, Manon; Wurtz, Nathalie; Rolain, Jean-Marc; Colson, Philippe; La Scola, Bernard; Raoult, Didier
Title: In vitro testing of combined hydroxychloroquine and azithromycin on SARS-CoV-2 shows synergistic effect Cord-id: aku5atqh Document date: 2020_4_25
ID: aku5atqh
Snippet: Abstract Human coronaviruses SARS-CoV-2 appeared at the end of 2019 and led to a pandemic with high morbidity and mortality. As there are currently no effective drugs targeting this virus, drug repurposing represents a short-term strategy to treat millions of infected patients at low costs. Hydroxychloroquine showed an antiviral effect in vitro. In vivo it showed efficacy, especially when combined with azithromycin in a preliminary clinical trial. Here we demonstrate that the combination of hydr
Document: Abstract Human coronaviruses SARS-CoV-2 appeared at the end of 2019 and led to a pandemic with high morbidity and mortality. As there are currently no effective drugs targeting this virus, drug repurposing represents a short-term strategy to treat millions of infected patients at low costs. Hydroxychloroquine showed an antiviral effect in vitro. In vivo it showed efficacy, especially when combined with azithromycin in a preliminary clinical trial. Here we demonstrate that the combination of hydroxychloroquine and azithromycin has a synergistic effect in vitro on SARS-CoV-2 at concentrations compatible with that obtained in human lung.
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