The Art of Prevention: COVID-19 Vaccine Preparedness for the Dermatologist

Rice, Shauna M.; Ferree, Sarah D.; Atanaskova Mesinkovska, Natasha; Shadi Kourosh, Arianne

As COVID-19 vaccinations begin, dermatologists must be aware of the cutaneous adverse events reported in the clinical trials, including injection site and hypersensitivity reactions, and emerging evidence of dermal filler injection reactions following vaccination. The filler reaction may represent development of a delayed-type hypersensitivity in the setting of another immunologic trigger, i.e. the vaccine. Upon literature review of similar reactions, their pathophysiology and management, we present a set of timely clinical considerations for counseling, prevention and management of the possible cutaneous sequelae of the COVID-19 vaccine, and encourage documentation of vaccine-related reactions to aid the safety-data collection in the Vaccine Adverse Event Reporting System and the American Academy of Dermatology COVID-19 Registry.