Author: Yasunori Watanabe; Zachary T. Berndsen; Jayna Raghwani; Gemma E. Seabright; Joel D. Allen; Jason S. McLellan; Ian A. Wilson; Thomas A. Bowden; Andrew B. Ward; Max Crispin
Title: Vulnerabilities in coronavirus glycan shields despite extensive glycosylation Document date: 2020_2_21
ID: bnnt05fn_24
Snippet: We then investigated the glycan shield densities of seven viral class I fusion proteins using a global structural approach which was calculated by dividing the number of amino-acids that interact with glycans by the number of solvent-accessible amino-acid residues of each respective glycoprotein and plotted this against oligomannose abundance. A strong correlation was observed (Fig. 6 ) and viruses historically classified as "evasion strong" 59 h.....
Document: We then investigated the glycan shield densities of seven viral class I fusion proteins using a global structural approach which was calculated by dividing the number of amino-acids that interact with glycans by the number of solvent-accessible amino-acid residues of each respective glycoprotein and plotted this against oligomannose abundance. A strong correlation was observed (Fig. 6 ) and viruses historically classified as "evasion strong" 59 had significantly elevated glycan shield densities and oligomannose abundance, which underscores the importance of glycan shielding in immune evasion. Fig. 5 ). The number of amino-acid residues interacting with N-linked glycans was divided by the number of solventaccessible amino-acid residues of the glycoprotein as a measure for global glycan shield density. All viral glycoproteins analysed were expressed as trimers in HEK 293F cells apart from LASV GPC, which was derived from virus-like particles from Madin-Darby canine kidney II cells.
Search related documents:
Co phrase search for related documents- amino acid and glycan shield: 1, 2, 3, 4, 5, 6
- amino acid and glycan shield density: 1, 2
- amino acid and immune evasion: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25
- amino acid residue and fusion protein: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10
- amino acid residue and glycan shield: 1
- amino acid residue and immune evasion: 1, 2, 3
- fusion protein and glycan interact: 1
- fusion protein and glycan shield: 1, 2
- fusion protein and glycan shielding: 1
- fusion protein and immune evasion: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10
- glycan interact and immune evasion: 1
- glycan shield and immune evasion: 1, 2, 3, 4, 5, 6, 7, 8
- glycan shield density and immune evasion: 1, 2
- glycan shielding and immune evasion: 1, 2, 3, 4, 5
- glycan shielding and immune evasion glycan shielding: 1, 2, 3
Co phrase search for related documents, hyperlinks ordered by date