Selected article for: "adaptive innate immune system and immune response"

Author: Wallin, Johan; Svenningsson, Per
Title: Potential Effects of Leukotriene Receptor Antagonist Montelukast in Treatment of Neuroinflammation in Parkinson’s Disease
  • Cord-id: iscloqqk
  • Document date: 2021_5_25
  • ID: iscloqqk
    Snippet: Parkinson’s disease (PD) is a neurodegenerative disorder where misfolded alpha-synuclein-enriched aggregates called Lewy bodies are central in pathogenesis. No neuroprotective or disease-modifying treatments are currently available. Parkinson’s disease is considered a multifactorial disease and evidence from multiple patient studies and animal models has shown a significant immune component during the course of the disease, highlighting immunomodulation as a potential treatment strategy. The
    Document: Parkinson’s disease (PD) is a neurodegenerative disorder where misfolded alpha-synuclein-enriched aggregates called Lewy bodies are central in pathogenesis. No neuroprotective or disease-modifying treatments are currently available. Parkinson’s disease is considered a multifactorial disease and evidence from multiple patient studies and animal models has shown a significant immune component during the course of the disease, highlighting immunomodulation as a potential treatment strategy. The immune changes occur centrally, involving microglia and astrocytes but also peripherally with changes to the innate and adaptive immune system. Here, we review current understanding of different components of the PD immune response with a particular emphasis on the leukotriene pathway. We will also describe evidence of montelukast, a leukotriene receptor antagonist, as a possible anti-inflammatory treatment for PD.

    Search related documents:
    Co phrase search for related documents
    • acetylcholine receptor and activation signaling: 1
    • acetylcholine receptor and ad disease: 1, 2
    • acetylcholine receptor and lung tissue: 1, 2, 3
    • activate microglia and ad disease: 1, 2
    • activate microglia and ad pathology: 1
    • activate microglia and lymph system: 1