Selected article for: "host cell and protein receptor"
Author: Chuang Liu; Yang Yang; Yuanzhu Gao; Chenguang Shen; Bin Ju; Congcong Liu; Xian Tang; Jinli Wei; Xiaomin Ma; Weilong Liu; Shuman Xu; Yingxia Liu; Jing Yuan; Jing Wu; Zheng Liu; Zheng Zhang; Peiyi Wang; Lei Liu
Title: Viral Architecture of SARS-CoV-2 with Post-Fusion Spike Revealed by Cryo-EM
  • Document date: 2020_3_5
    • ID: cr22vp8b_4
    Snippet: The S1 subunit facilitates attachment to the host cells and the S2 subunit is involved in subsequent fusion of the virus and host membrane [9] . Several recent studies considering the structure of SARS-CoV-2 were all focused on the S protein. Wrapp et al. [10] reported a structure at 3.5 Ã… resolution of SARS-CoV-2 S protein. Yan et al. [11] reported the complex structure of SARS-CoV-2 S protein with human host cell binding receptor angiotensin-c.....
    Document: The S1 subunit facilitates attachment to the host cells and the S2 subunit is involved in subsequent fusion of the virus and host membrane [9] . Several recent studies considering the structure of SARS-CoV-2 were all focused on the S protein. Wrapp et al. [10] reported a structure at 3.5 Ã… resolution of SARS-CoV-2 S protein. Yan et al. [11] reported the complex structure of SARS-CoV-2 S protein with human host cell binding receptor angiotensin-converting enzyme 2 (ACE2). Lan et al. [12] reported crystal structure of SARS-CoV-2 S protein's receptor binding domain (RBD) region binding with ACE2. However, all proteins mentioned above are engineered in laboratory by recombinant expression system, not from real virus and the structure as whole of virion is thus still lacking.

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