Author: Héctor Cervera; Silvia Ambrós; Guillermo P. Bernet; Guillermo Rodrigo; Santiago F. Elena
Title: Viral fitness predicts the magnitude and direction of perturbations in the infected host transcriptome Document date: 2017_10_20
ID: 0qmsripp_13
Snippet: Following from our working hypothesis, if the WT virus has evolved to optimize its interaction with the host, it is logical that small departures in viral fitness will be associated with small deviations between the transcriptomes of plants infected with the WT virus and with viruses whose fitness are close to the WT. Conversely, the less similar fitness between the WT and mutant viruses, the more dissimilar would be the transcriptional profiles .....
Document: Following from our working hypothesis, if the WT virus has evolved to optimize its interaction with the host, it is logical that small departures in viral fitness will be associated with small deviations between the transcriptomes of plants infected with the WT virus and with viruses whose fitness are close to the WT. Conversely, the less similar fitness between the WT and mutant viruses, the more dissimilar would be the transcriptional profiles of infected plants. To test this prediction, we have explored (i) the correlation between the similarity of transcriptional profiles of plants infected with the WT TEV and with each mutant (again using Pearson's r) and
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