Author: Amrita Roy; Liangzhong Lim; Shagun Srivastava; Jianxing Song
Title: Unique properties of Zika NS2B-NS3pro complexes as decoded by experiments and MD simulations Document date: 2016_9_28
ID: l82aakrk_3
Snippet: Zika virus with a single stranded, positive sense RNA genome of 10.7 kb belongs to the flavivirus genus, which also contains Dengue, yellow fever, West Nile, Japanese encephalitis, and tick-borne encephalitis viruses (4, 10) . Zika virus shares a high degree of sequence and structural homology with other flaviviruses particularly Dengue virus, thus resulting in immunological cross-reactivity (11). Seriously, the current Zika outbreaks are largely.....
Document: Zika virus with a single stranded, positive sense RNA genome of 10.7 kb belongs to the flavivirus genus, which also contains Dengue, yellow fever, West Nile, Japanese encephalitis, and tick-borne encephalitis viruses (4, 10) . Zika virus shares a high degree of sequence and structural homology with other flaviviruses particularly Dengue virus, thus resulting in immunological cross-reactivity (11). Seriously, the current Zika outbreaks are largely localized within dengue-endemic areas, it is thus proposed that preexisting dengueinduced antibodies may enhance Zika infection by antibody-dependent enhancement (ADE), a factor that makes the vaccine approaches extremely challenging (11).
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