Selected article for: "active viral replication and viral replication"
Author: Sha Fu; Xiaoyu Fu; Yang Song; Min Li; Pin-hua Pan; Tao Tang; Chunhu Zhang; Tiejian Jiang; Deming Tan; Xuegong Fan; Xinping Sha; Jingdong Ma; Yan Huang; Shaling Li; Yixiang Zheng; Zhaoxin Qian; Zeng Xiong; Lizhi Xiao; Huibao Long; Jianghai Chen; Yi Ouyang
Title: Virologic and clinical characteristics for prognosis of severe COVID-19: a retrospective observational study in Wuhan, China
  • Document date: 2020_4_6
    • ID: 4989atst_34
    Snippet: The copyright holder for this preprint (which was not peer-reviewed) is . https://doi.org/10.1101/2020.04.03.20051763 doi: medRxiv preprint infected patients. In addition, it was found that the interval of viral shedding in patients with poor recovery was markedly prolonged. Importantly, both the IgM and IgG of SARS-CoV-2 in the patients with poor recovery remained positive during the late stage of the disease. This indicated that these patients .....
    Document: The copyright holder for this preprint (which was not peer-reviewed) is . https://doi.org/10.1101/2020.04.03.20051763 doi: medRxiv preprint infected patients. In addition, it was found that the interval of viral shedding in patients with poor recovery was markedly prolonged. Importantly, both the IgM and IgG of SARS-CoV-2 in the patients with poor recovery remained positive during the late stage of the disease. This indicated that these patients might have active viral replication in the upper airway, and that persistent viral shedding might be directly linked to the poor recovery of patients with COVID-19. Supporting this notion, it was found that the SARS-CoV-2 RNA could persist until death in non-survivors 17 . Based on the delayed interval of viral shedding pattern and the serologic features of SARS-CoV-2, it is proposed that severe-condition patients with COVID-19 may need at least three negative PCR results with an interval of a few days. In addition, dynamic detection to improve the presence of IgM-negative should also be evaluated to guide discharge planning for COVID-19 patients.

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