Selected article for: "allele frequency and significant difference"
Author: Itoyama, Satoru; Keicho, Naoto; Quy, Tran; Phi, Nguyen Chi; Long, Hoang Thuy; Ha, Le Dang; Ban, Vo Van; Ohashi, Jun; Hijikata, Minako; Matsushita, Ikumi; Kawana, Akihiko; Yanai, Hideki; Kirikae, Teruo; Kuratsuji, Tadatoshi; Sasazuki, Takehiko
Title: ACE1 polymorphism and progression of SARS
  • Cord-id: j4600733
  • Document date: 2004_10_22
    • ID: j4600733
    Snippet: We have hypothesized that genetic predisposition influences the progression of SARS. Angiotensin converting enzyme (ACE1) insertion/deletion (I/D) polymorphism was previously reported to show association with the adult respiratory distress syndrome, which is also thought to play a key role in damaging the lung tissues in SARS cases. This time, the polymorphism was genotyped in 44 Vietnamese SARS cases, with 103 healthy controls who had had a contact with the SARS patients and 50 controls without
    Document: We have hypothesized that genetic predisposition influences the progression of SARS. Angiotensin converting enzyme (ACE1) insertion/deletion (I/D) polymorphism was previously reported to show association with the adult respiratory distress syndrome, which is also thought to play a key role in damaging the lung tissues in SARS cases. This time, the polymorphism was genotyped in 44 Vietnamese SARS cases, with 103 healthy controls who had had a contact with the SARS patients and 50 controls without any contact history. SARS cases were divided into either non-hypoxemic or hypoxemic groups. Despite the small sample size, the frequency of the D allele was significantly higher in the hypoxemic group than in the non-hypoxemic group (p = 0.013), whereas there was no significant difference between the SARS cases and controls, irrespective of a contact history. ACE1 might be one of the candidate genes that influence the progression of pneumonia in SARS.

    Search related documents:
    Co phrase search for related documents
    • acute ards respiratory distress syndrome and logistic regression analysis: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24
    • acute ards respiratory distress syndrome and low middle: 1, 2, 3, 4, 5, 6, 7, 8, 9
    • acute ards respiratory distress syndrome and lung epithelium endothelium: 1, 2
    • acute ards respiratory distress syndrome and lung field: 1, 2, 3
    • acute ards respiratory distress syndrome and lung pathological analysis: 1
    • acute ards respiratory distress syndrome and lung sars progression: 1
    • acute ards respiratory distress syndrome present and logistic regression: 1
    • acute phase and local serum: 1, 2
    • acute phase and logistic regression: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35
    • acute phase and logistic regression analysis: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13
    • acute stage and logistic regression: 1, 2, 3, 4, 5
    • acute stage and logistic regression analysis: 1
    • local guideline and low middle: 1