Selected article for: "bi transgenic model and mild bi transgenic model"
Author: Takako I. Jones; Guo-Liang Chew; Pamela Barraza-Flores; Spencer Schreier; Monique Ramirez; Ryan D. Wuebbles; Dean J. Burkin; Robert K. Bradley; Peter L. Jones
Title: Transgenic mice expressing tunable levels of DUX4 develop characteristic facioscapulohumeral muscular dystrophy-like pathophysiology ranging in severity
  • Document date: 2018_11_15
    • ID: 1yto01tr_56
    Snippet: Similarly, the severe model showed TUNEL positive nuclei by SD6, with a dramatic increase by SD9 ( Figure 13A-C) . Interestingly, muscles from the bi-transgenic mild model showed no indication of apoptosis and were similar to muscles from ACTA1-MCM controls (Figure13, compare panels D and L). Thus, the moderate and severe models show dose-dependent DUX4-FL-induced apoptosis following a similar time course as muscle weakness and decreased function.....
    Document: Similarly, the severe model showed TUNEL positive nuclei by SD6, with a dramatic increase by SD9 ( Figure 13A-C) . Interestingly, muscles from the bi-transgenic mild model showed no indication of apoptosis and were similar to muscles from ACTA1-MCM controls (Figure13, compare panels D and L). Thus, the moderate and severe models show dose-dependent DUX4-FL-induced apoptosis following a similar time course as muscle weakness and decreased function, and correlating with the activation of muscle regeneration.

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