Author: Xavier Hernandez-Alias; Martin Schaefer; Luis Serrano
Title: Translational adaptation of human viruses to the tissues they infect Document date: 2020_4_7
ID: 0rk2dw4e_4
Snippet: The SARS-CoV-2 coronavirus constitutes the etiologic agent of the biggest pandemic of the 21 st century, causing the COVID-19 pneumonia-like disease. Originated in Wuhan (China), the virus has already caused 40,598 deaths as of 1 st April 2020 20 . In this context, recent scientific efforts suggest that the novel coronavirus strain has evolved to preferentially infect nasal goblet and ciliated cells as well as the type-2 alveolar epithelial cells.....
Document: The SARS-CoV-2 coronavirus constitutes the etiologic agent of the biggest pandemic of the 21 st century, causing the COVID-19 pneumonia-like disease. Originated in Wuhan (China), the virus has already caused 40,598 deaths as of 1 st April 2020 20 . In this context, recent scientific efforts suggest that the novel coronavirus strain has evolved to preferentially infect nasal goblet and ciliated cells as well as the type-2 alveolar epithelial cells 21, 22 . However, some non-respiratory-related symptoms such as loss of smell and taste hint as well to other tropism potential outside the respiratory tract 23, 24 . In terms of translational efficiency, we here discover that the coronavirus proteome is especially adapted not only to upper respiratory airways and alveoli, but also to the gastrointestinal tract and brain.
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