Author: Yujia Xiang; Quan Zou; Lilin Zhao
Title: VPTMdb: a viral post-translational modification database Document date: 2020_4_2
ID: kl99afiu_3
Snippet: Post-translational modifications (PTMs) play a critical role in current proteomics research and regulate protein functions by altering protein interactions, stability, activity, and subcellular localization. Posttranslation modifications of viral proteins are relevant throughout various stages of the pathogen life cycle, especially viral infections and genome replication. For example, during entry, the influenza virus carries unanchored ubiquitin.....
Document: Post-translational modifications (PTMs) play a critical role in current proteomics research and regulate protein functions by altering protein interactions, stability, activity, and subcellular localization. Posttranslation modifications of viral proteins are relevant throughout various stages of the pathogen life cycle, especially viral infections and genome replication. For example, during entry, the influenza virus carries unanchored ubiquitin chains to engage the host cell's aggresome system (Banerjee, et al., 2014) . Once inside the host cell, viral PTMs regulating infecting process of HSV-1 encode ICP0 protein to degrade host proteins via ubiquitination and sumoylation (Randow and Lehner, 2009 ). In the viral life circle, the HIV-1 Tat protein ser-16 phosphorylated site regulates HIV-1 transcription (Ivanov, et al., 2018) . Therefore, knowledge of viral PTMs is of great significant to understanding the molecular mechanisms underlying viral infections and recognizing potential drug targets. In recent years, several studies have identified multiple viral PTMs (Kulej, et al., 2017; Scaturro, et al., 2018; Zheng, et al., 2018) ; thus, establishing a database to provide relevant knowledge is important.
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