Selected article for: "acute angiotensin and lung injury"
Author: Changhai Lei; Wenyan Fu; Kewen Qian; Tian Li; Sheng Zhang; Min Ding; Shi Hu
Title: Potent neutralization of 2019 novel coronavirus by recombinant ACE2-Ig
  • Document date: 2020_2_2
    • ID: aeuy92bx_3
    Snippet: As ACE2 is a key player in the hormonal cascades that plays a central role in the homeostatic control of cardiorenal actions, earlier researchers had exerted effect on the pharmacodynamics studies of recombinant ACE2 (rACE2) to protect against severe acute lung injury and acute Ang II-induced hypertension 4-6 . In mice models, administration of rACE2 also showed to adverse myocardial remodelling, attenuate Ang II-induced heart hypertrophy and car.....
    Document: As ACE2 is a key player in the hormonal cascades that plays a central role in the homeostatic control of cardiorenal actions, earlier researchers had exerted effect on the pharmacodynamics studies of recombinant ACE2 (rACE2) to protect against severe acute lung injury and acute Ang II-induced hypertension 4-6 . In mice models, administration of rACE2 also showed to adverse myocardial remodelling, attenuate Ang II-induced heart hypertrophy and cardiac dysfunction, 7 , as well as renal oxidative stress, inflammation, and fibrosis. 8, 9 However, both in humans and mice 10, 11 , rACE2 exhibits fast clearance rates with a reported half-life of only hours by pharmacokinetic studies. Recently, fusion protein of rACE2 with an Fc fragment (rACE2-Fc) showed organ protection in both acute and chronic models of angiotensin II-dependent hypertension in mice 12 , interestingly, the fusion protein also showed long-lasting effects.

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