Selected article for: "inflammasome activation and viral infection"
Author: Zhao, Chunyuan; Zhao, Wei
Title: NLRP3 Inflammasome—A Key Player in Antiviral Responses
  • Cord-id: 4ikxmpyn
  • Document date: 2020_2_18
    • ID: 4ikxmpyn
    Snippet: The NACHT, LRR, and PYD domains-containing protein 3 (NLRP3) inflammasome is an oligomeric complex comprised of the NOD-like receptor NLRP3, the adaptor ASC, and caspase-1. This complex is crucial to the host's defense against microbes as it promotes IL-1β and IL-18 secretion and induces pyroptosis. NLRP3 recognizes variety of pathogen-associated molecular patterns (PAMPs) and danger-associated molecular patterns (DAMPs) generated during viral replication that triggers the NLRP3 inflammasome-de
    Document: The NACHT, LRR, and PYD domains-containing protein 3 (NLRP3) inflammasome is an oligomeric complex comprised of the NOD-like receptor NLRP3, the adaptor ASC, and caspase-1. This complex is crucial to the host's defense against microbes as it promotes IL-1β and IL-18 secretion and induces pyroptosis. NLRP3 recognizes variety of pathogen-associated molecular patterns (PAMPs) and danger-associated molecular patterns (DAMPs) generated during viral replication that triggers the NLRP3 inflammasome-dependent antiviral immune responses and facilitates viral eradication. Meanwhile, several viruses have evolved elaborate strategies to evade the immune system by targeting the NLRP3 inflammasome. In this review, we will focus on the crosstalk between the NLRP3 inflammasome and viruses, provide an overview of viral infection-induced NLRP3 inflammasome activation, and the immune escape strategies of viruses through their modulation of the NLRP3 inflammasome activity.

    Search related documents:
    Co phrase search for related documents
    • acid inducible and activation signal: 1, 2
    • acid inducible and acute sars cov respiratory syndrome coronavirus: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12
    • acid inducible and adaptive immune response: 1, 2, 3, 4, 5
    • acid inducible gene and activation enhance: 1
    • acid inducible gene and activation signal: 1, 2
    • acid inducible gene and acute sars cov respiratory syndrome coronavirus: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12
    • acid inducible gene and adaptive immune response: 1, 2, 3, 4, 5
    • activation enhance and acute sars cov respiratory syndrome coronavirus: 1, 2, 3
    • activation enhance and adaptive immune response: 1, 2
    • activation inflammasome assembly and acute sars cov respiratory syndrome coronavirus: 1
    • activation signal and acute sars cov respiratory syndrome coronavirus: 1, 2, 3, 4, 5, 6, 7, 8, 9
    • activation step and acute sars cov respiratory syndrome coronavirus: 1, 2