Author: Zaninotto, Martina; Maria Mion, Monica; Marchioro, Lucio; Padoan, Andrea; Plebani, Mario
Title: Endothelial dysfunction and Mid-Regional proAdrenomedullin: what role in SARS-CoV-2 infected Patients? Cord-id: b1c8gmqx Document date: 2021_9_20
ID: b1c8gmqx
Snippet: Background Endothelial dysfunction, a major complication of SARS-CoV-2 infectionplaying a key-role in multi-organ damage, carries high risk of mortality. Aim To investigate the potential role of Mid-Regional pro-Adrenomedullin (MR-proADM) in detecting endothelial damage with a view to stratifying the risk of adverse events (length of stay, death, admission in Intensive Care Unit) and/or disease resolution. Materials and Methods In 135 consecutive patients with SARS-CoV-2 infection, MR-proADM was
Document: Background Endothelial dysfunction, a major complication of SARS-CoV-2 infectionplaying a key-role in multi-organ damage, carries high risk of mortality. Aim To investigate the potential role of Mid-Regional pro-Adrenomedullin (MR-proADM) in detecting endothelial damage with a view to stratifying the risk of adverse events (length of stay, death, admission in Intensive Care Unit) and/or disease resolution. Materials and Methods In 135 consecutive patients with SARS-CoV-2 infection, MR-proADM was measured in EDTA-K2 plasma samples using B.R.A.H.M.S. KRYPTOR® COMPACT Plus method (Thermo Fisher Scientific, Hennigsdorf, Germany) Results Patients were subdivided into three groups based on their MR-proADM value (nmol/L): 1 (n=20, MR-proADM≤0.55); 2 (n=82, 0.551.50). The higher the MR-proADM value, the greater the patients’ age, the more frequent the occurrence of pneumonia, the requiring of more aggressive treatment, the longer the hospitalization and the more frequent a fatal event. Significant differences were found between the three groups for MR-proADM, White-blood cell count, Neutrophil count, D-dimer, C-reactive Protein, Procalcitonin and hs-Troponin I. At logistic regression,it was found that MR-proADM and Log10 D-dimer were the most significant predictors of adverse events. Conclusion The findings made in the present study highlight the relevance of MR-proADM values in providing clinically useful information, particularly for stratifying COVID-19 patients according to the risk of a more severe form of disease and to the development of adverse events.
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