Prognosis of rash and chilblain-like lesions among outpatients with COVID-19: a large cohort study

Mascitti, Hélène; Jourdain, Patrick; Bleibtreu, Alexandre; Jaulmes, Luc; Dechartres, Agnès; Lescure, Xavier; Yordanov, Youri; Dinh, Aurélien

In a large regional observational cohort study of adult (≥ 18 years), outpatients with COVID-19, prevalence, characteristics, and outcome of patients with rash and/or chilblain-like lesions (CLL), compared with population without cutaneous features, were studied. In total, 28,957 outpatients were included; the prevalence of rash and CCL were 9.5% and 3.7%, respectively. Presence of rash was significantly associated with presence of asthenia, shivers or myalgia, respiratory and gastro-intestinal symptoms, and anosmia/ageusia. The presence of CCL was associated with chest pain, chest oppression, nausea/vomiting, and anosmia/ageusia. Patients with CCL were significantly less prone to an unfavourable outcome (hospitalization or death). SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s10096-021-04305-3.