Selected article for: "action mechanism and low effect"
Author: Daniel Bean; Zeljko Kraljevic; Thomas Searle; Rebecca Bendayan; Andrew Pickles; Amos Folarin; Lukasz Roguski; Kawsar Noor; Anthony Shek; Kevin o'gallagher; Rosita Zakeri; Ajay Shah; James Teo; Richard JB Dobson
Title: Treatment with ACE-inhibitors is associated with less severe disease with SARS-Covid-19 infection in a multi-site UK acute Hospital Trust
  • Document date: 2020_4_11
    • ID: 60wcvkbn_18
    Snippet: This study suggests that ACE-inhibitors do not increase the severity of COVID-19 disease as hypothesised 4-7 but may reduce severity. This holds true even after adjusting for conditions where ACEi may be used (hypertension, diabetes mellitus, ischaemic heart disease and heart failure). No meaningful comment can be made about ARB effect given the low prevalence of their use in this cohort, although ARB have a different mechanism of action compared.....
    Document: This study suggests that ACE-inhibitors do not increase the severity of COVID-19 disease as hypothesised 4-7 but may reduce severity. This holds true even after adjusting for conditions where ACEi may be used (hypertension, diabetes mellitus, ischaemic heart disease and heart failure). No meaningful comment can be made about ARB effect given the low prevalence of their use in this cohort, although ARB have a different mechanism of action compared to ACEi.

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