Cell membrane proteins with high N-glycosylation, high expression and multiple interaction partners are preferred by mammalian viruses as receptors

Zhang, Zheng; Zhu, Zhaozhong; Chen, Wenjun; Cai, Zena; Xu, Beibei; Tan, Zhiying; Wu, Aiping; Ge, Xingyi; Guo, Xinhong; Tan, Zhongyang; Xia, Zanxian; Zhu, Haizhen; Jiang, Taijiao; Peng, Yousong

MOTIVATION: Receptor mediated entry is the first step for viral infection. However, the question of how viruses select receptors remains unanswered. RESULTS: Here, by manually curating a high-quality database of 268 pairs of mammalian virus–host receptor interaction, which included 128 unique viral species or sub-species and 119 virus receptors, we found the viral receptors are structurally and functionally diverse, yet they had several common features when compared to other cell membrane proteins: more protein domains, higher level of N-glycosylation, higher ratio of self-interaction and more interaction partners, and higher expression in most tissues of the host. This study could deepen our understanding of virus–receptor interaction. AVAILABILITY AND IMPLEMENTATION: The database of mammalian virus–host receptor interaction is available at http://www.computationalbiology.cn: 5000/viralReceptor. SUPPLEMENTARY INFORMATION: Supplementary data are available at Bioinformatics online.