Selected article for: "activity work and lung function"
Author: Beitia, Maider; Delgado, Diego; Sánchez, Pello; Vallejo de la Cueva, Ana; Cugat, José Ramón; Sánchez, Mikel
Title: Platelet Lysate Nebulization Protocol for the Treatment of COVID-19 and Its Sequels: Proof of Concept and Scientific Rationale
  • Cord-id: 98x61ly4
  • Document date: 2021_2_12
    • ID: 98x61ly4
    Snippet: One of the most severe effects of coronavirus disease 2019 (COVID-19) is lung disorders such as acute respiratory distress syndrome. In the absence of effective treatments, it is necessary to search for new therapies and therapeutic targets. Platelets play a fundamental role in respiratory disorders resulting from viral infections, being the first line of defense against viruses and essential in maintaining lung function. The direct application of platelet lysate (PL) obtained from the platelet-
    Document: One of the most severe effects of coronavirus disease 2019 (COVID-19) is lung disorders such as acute respiratory distress syndrome. In the absence of effective treatments, it is necessary to search for new therapies and therapeutic targets. Platelets play a fundamental role in respiratory disorders resulting from viral infections, being the first line of defense against viruses and essential in maintaining lung function. The direct application of platelet lysate (PL) obtained from the platelet-rich plasma of healthy donors could help in the improvement of the patient due its anti-inflammatory, immunomodulatory, antifibrotic, and repairing effects. This work evaluates PL nebulization by analyzing its levels of growth factors and its biological activity on lung fibroblast cell cultures, besides describing a scientific basis for its use in this kind of pathology. The data of the work suggest that the molecular levels and biological activity of the PL are maintained after nebulization. Airway administration would allow acting directly on the lung tissue modulating inflammation and stimulating reparative processes on key structures such as the alveolocapillary barrier, improving the disease and sequels. The protocol developed in this work is a first step for the study of nebulized PL both in animal experimentation and in clinical trials.

    Search related documents:
    Co phrase search for related documents
    • acute ards respiratory distress syndrome and local administration: 1
    • acute ards respiratory distress syndrome and local general: 1
    • acute ards respiratory distress syndrome and local infiltration: 1
    • acute ards respiratory distress syndrome and local instillation: 1
    • acute ards respiratory distress syndrome and local treatment: 1, 2, 3, 4, 5
    • acute ards respiratory distress syndrome and low mortality: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24
    • acute ards respiratory distress syndrome and low mortality rate: 1, 2, 3, 4
    • acute ards respiratory distress syndrome and lps induce: 1, 2, 3, 4, 5, 6
    • acute ards respiratory distress syndrome and lung biology: 1, 2
    • acute ards respiratory distress syndrome and lung bone marrow: 1, 2
    • acute ards respiratory distress syndrome and lung condition: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17
    • acute ards respiratory distress syndrome and lung culture: 1, 2
    • acute ards respiratory distress syndrome and lung fibroblast: 1, 2
    • acute ards respiratory distress syndrome and lung fibrosis: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39
    • acute ards respiratory distress syndrome and lung function inflammation: 1, 2, 3, 4, 5, 6
    • acute ards respiratory distress syndrome and lung importance: 1, 2, 3
    • acute ards respiratory distress syndrome and lung pathology: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20
    • acute ards respiratory distress syndrome and lung problem: 1
    • acute ards respiratory distress syndrome and lung reach: 1, 2