Author: Prashali Bansal; Johannes Madlung; Kristina Schaaf; Boris Macek; Fulvia Bono
Title: An interaction network of RNA-binding proteins involved in Drosophila oogenesis Document date: 2020_1_9
ID: 2f9nc2to_55
Snippet: Along with several known regulators of maternal mRNAs, we identified the protein products of many previously uncharacterized genes. One such example is CG5726, which encodes for a protein with a MIF4Glike domain. This domain is found in many proteins involved in RNA metabolism including translation initiation factors, NMD factors and nuclear cap-binding proteins (65, [119] [120] [121] [122] . With no identifiable orthologs in humans, CG5726 prote.....
Document: Along with several known regulators of maternal mRNAs, we identified the protein products of many previously uncharacterized genes. One such example is CG5726, which encodes for a protein with a MIF4Glike domain. This domain is found in many proteins involved in RNA metabolism including translation initiation factors, NMD factors and nuclear cap-binding proteins (65, [119] [120] [121] [122] . With no identifiable orthologs in humans, CG5726 protein shows up to 50% sequence identity among Drosophilids. In early embryos of Drosophila melanogaster, CG5726 interacts with short Osk (108) . In this study, we found CG5726 to be interacting with multiple RBPs: Glo, Hrp48 and Vas, suggesting its possible role in translational regulation.
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