Selected article for: "additional drug and long short"
Author: Sencanski, Milan; Perovic, Vladimir; Pajovic, Snezana B.; Adzic, Miroslav; Paessler, Slobodan; Glisic, Sanja
Title: Drug Repurposing for Candidate SARS-CoV-2 Main Protease Inhibitors by a Novel In Silico Method
  • Cord-id: 4m4s7ms6
  • Document date: 2020_8_23
    • ID: 4m4s7ms6
    Snippet: The SARS-CoV-2 outbreak caused an unprecedented global public health threat, having a high transmission rate with currently no drugs or vaccines approved. An alternative powerful additional approach to counteract COVID-19 is in silico drug repurposing. The SARS-CoV-2 main protease is essential for viral replication and an attractive drug target. In this study, we used the virtual screening protocol with both long-range and short-range interactions to select candidate SARS-CoV-2 main protease inh
    Document: The SARS-CoV-2 outbreak caused an unprecedented global public health threat, having a high transmission rate with currently no drugs or vaccines approved. An alternative powerful additional approach to counteract COVID-19 is in silico drug repurposing. The SARS-CoV-2 main protease is essential for viral replication and an attractive drug target. In this study, we used the virtual screening protocol with both long-range and short-range interactions to select candidate SARS-CoV-2 main protease inhibitors. First, the Informational spectrum method applied for small molecules was used for searching the Drugbank database and further followed by molecular docking. After in silico screening of drug space, we identified 57 drugs as potential SARS-CoV-2 main protease inhibitors that we propose for further experimental testing.

    Search related documents:
    Co phrase search for related documents
    • ace inhibitor and active site: 1, 2
    • ace inhibitor and long short: 1
    • active site and additional strategy: 1
    • active site and long range: 1, 2, 3, 4, 5
    • active site and long short: 1, 2, 3
    • additional strategy and long short: 1, 2