Author: Martins, A. L. V.; Silva, F. A.; Ramos, L. B.; Ribeiro, R. C.; Annoni, F.; Cardoso, A.; Oliveira, G. C.; Martins, J. C.; Santos, D. M.; Zivianni, B.; Campagnole-Santos, M. J.; Pereira, D. A. A.; Taccone, F. S.; Braga, T. V.; Santos, R. A. S.
Title: Increased circulating levels of angiotensin-(1-7) in severely ill COVID-19 patients Cord-id: 9essekf3 Document date: 2021_2_3
ID: 9essekf3
Snippet: The mono-carboxypeptidase Angiotensin-Converting Enzyme 2 (ACE2) is an important player of the renin-angiotensin system (RAS). ACE2 is also the receptor for SARS-CoV-2, the new coronavirus that causes COVID-19. It has been hypothesized that following SARS-CoV-2/ACE2 internalization Ang II level would increase in parallel to a decrease of Ang-(1-7) in COVID-19 patients. In this preliminary report, we analyzed the plasma levels of angiotensin peptides in 19 severe COVID-19 patients and 19 non-COVI
Document: The mono-carboxypeptidase Angiotensin-Converting Enzyme 2 (ACE2) is an important player of the renin-angiotensin system (RAS). ACE2 is also the receptor for SARS-CoV-2, the new coronavirus that causes COVID-19. It has been hypothesized that following SARS-CoV-2/ACE2 internalization Ang II level would increase in parallel to a decrease of Ang-(1-7) in COVID-19 patients. In this preliminary report, we analyzed the plasma levels of angiotensin peptides in 19 severe COVID-19 patients and 19 non-COVID-19 volunteers. Unexpectedly, a significant increase in circulating Ang-(1-7) and lower Ang II plasma level were found in critically ill COVID-19 patients. Accordingly, an increased Ang-(1-7)/ Ang II ratio was observed in COVID-19 suggesting a RAS dysregulation toward an increased formation of Ang-(1-7) in these patients.
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