Author: Satria P. Sajuthi; Peter DeFord; Nathan D. Jackson; Michael T. Montgomery; Jamie L. Everman; Cydney L. Rios; Elmar Pruesse; James D. Nolin; Elizabeth G. Plender; Michael E. Wechsler; Angel CY Mak; Celeste Eng; Sandra Salazar; Vivian Medina; Eric M. Wohlford; Scott Huntsman; Deborah A. Nickerson; Soren Germer; Michael C. Zody; Gonçalo Abecasis; Hyun Min Kang; Kenneth M. Rice; Rajesh Kumar; Sam Oh; Jose Rodriguez-Santana; Esteban G. Burchard; Max A. Seibold
Title: Type 2 and interferon inflammation strongly regulate SARS-CoV-2 related gene expression in the airway epithelium Document date: 2020_4_10
ID: mj8ebo7i_7
Snippet: To further explore this increase in cytotoxic immune response and other potential 349 pathways in CoV-infected individuals, we next performed a transcriptome-wide screen 350 for genes differentially expressed in CoV or HRV-infected groups compared to 351 uninfected individuals. These analyses revealed 2,515 differentially expressed genes 352 (DEGs) with CoV infection and 2,357 DEGs with HRV infection (FDR < 0.05 and log 2 FC 353 . CC-BY-NC-ND 4.0.....
Document: To further explore this increase in cytotoxic immune response and other potential 349 pathways in CoV-infected individuals, we next performed a transcriptome-wide screen 350 for genes differentially expressed in CoV or HRV-infected groups compared to 351 uninfected individuals. These analyses revealed 2,515 differentially expressed genes 352 (DEGs) with CoV infection and 2,357 DEGs with HRV infection (FDR < 0.05 and log 2 FC 353 . CC-BY-NC-ND 4.0 International license author/funder. It is made available under a The copyright holder for this preprint (which was not peer-reviewed) is the . https://doi.org/10.1101/2020.04.09.034454 doi: bioRxiv preprint > |0.5|), of which 35% and 31% were only observed with CoV and HRV infections, 354 respectively, based on our significance cutoff (Figure 6c ). Upstream regulator analysis 355 with IPA carried out separately on CoV and HRV infection response genes showed that 356 the top cytokines and transcription factors that may regulate these infections are shared 357 between the two virus families, including IL10, IL1B, IFNG, IFNA2, and STAT1 ( Figure 358 6d). One inferred upstream regulator of CoV response genes, IL-6, which was also 359 among the genes upregulated with CoV infection (log 2 FC=2.2, Figure 6e ), is especially 360 noteworthy considering that an IL-6 blocking antibody therapy is currently under 361 investigation for use in treatment of COVID-19 illnesses 24 . Additionally, we found ACE2 362 among the shared upregulated genes, reinforcing its upregulation in the course of 363 different respiratory virus infections (log 2 FC in CoV + =0.6, log 2 FC in HRV + =0.5, Figure 364 6e). 365
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