Author: Simonis, Alexander; Theobald, Sebastian J; Fätkenheuer, Gerd; Rybniker, Jan; Malin, Jakob J
Title: A comparative analysis of remdesivir and other repurposed antivirals against SARSâ€CoVâ€2 Cord-id: 5g1rw202 Document date: 2020_11_3
ID: 5g1rw202
Snippet: The ongoing SARSâ€CoVâ€2 pandemic stresses the need for effective antiviral drugs that can quickly be applied in order to reduce morbidity, mortality, and ideally viral transmission. By repurposing of broadly active antiviral drugs and compounds that are known to inhibit viral replication of related viruses, several advances could be made in the development of treatment strategies against COVIDâ€19. The nucleoside analog remdesivir, which is known for its potent in vitro activity against Ebol
Document: The ongoing SARSâ€CoVâ€2 pandemic stresses the need for effective antiviral drugs that can quickly be applied in order to reduce morbidity, mortality, and ideally viral transmission. By repurposing of broadly active antiviral drugs and compounds that are known to inhibit viral replication of related viruses, several advances could be made in the development of treatment strategies against COVIDâ€19. The nucleoside analog remdesivir, which is known for its potent in vitro activity against Ebolavirus and other RNA viruses, was recently shown to reduce the time to recovery in patients with severe COVIDâ€19. It is to date the only approved antiviral for treating COVIDâ€19. Here, we provide a mechanism and evidenceâ€based comparative review of remdesivir and other repurposed drugs with proven in vitro activity against SARSâ€CoVâ€2.
Search related documents:
Co phrase search for related documents- accessory protein and acute sars cov respiratory syndrome coronavirus: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35
- accessory protein and addition time: 1, 2
- accessory protein and lung damage: 1
- accessory protein and lung tissue: 1, 2
- accessory protein and lung virus: 1, 2
- accessory protein structural protein and acute respiratory syndrome: 1, 2, 3, 4
- accessory protein structural protein and acute sars cov respiratory syndrome coronavirus: 1, 2
Co phrase search for related documents, hyperlinks ordered by date