Author: Domingo, Esteban
Title: Mechanisms of viral emergence Cord-id: k6v4am7l Document date: 2010_2_5
ID: k6v4am7l
Snippet: A number of virologic and environmental factors are involved in the emergence and re-emergence of viral disease. Viruses do not conservatively occupy a single and permanent ecological niche. Rather, due to their intrinsic capacity for genetic change, and to the evolvability of fitness levels, viruses display a potential to parasitize alternative host species. Mutation, recombination and genome segment reassortment, and combination of these molecular events, produce complex and phenotypically div
Document: A number of virologic and environmental factors are involved in the emergence and re-emergence of viral disease. Viruses do not conservatively occupy a single and permanent ecological niche. Rather, due to their intrinsic capacity for genetic change, and to the evolvability of fitness levels, viruses display a potential to parasitize alternative host species. Mutation, recombination and genome segment reassortment, and combination of these molecular events, produce complex and phenotypically diverse populations of viruses, which constitute the raw material on which selection acts. The majority of emerging viral diseases of humans have a zoonotic origin. Sociologic and ecologic factors produce diverse and changing environments in which viral subpopulations have ample opportunities to be selected from intrinsically heterogeneous viral populations, particularly in the case of RNA viruses. In this manner, new human, animal and plant viruses have emerged periodically and, from all evidence, will continue to emerge. This article reviews some of the mechanisms that have been identified in viral emergence, with a focus on the importance of genetic variation of viruses, and on the general concept of biological complexity.
Search related documents:
Co phrase search for related documents- accessory essential and acute respiratory syndrome: 1, 2
- acquired aids immune deficiency syndrome and acute respiratory syndrome: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11
- acquisition mutation and adaptation process: 1
- acquisition mutation and adaptation process mutant spectra role: 1
- acquisition mutation and adaptive mutation: 1
- active recombination and acute respiratory syndrome: 1, 2
- active recombination and adaptive potential: 1
- active recombination display and adaptive potential: 1
- acute respiratory syndrome and adaptation process: 1, 2, 3
- acute respiratory syndrome and adaptive advantage: 1
- acute respiratory syndrome and adaptive mechanism: 1, 2, 3, 4, 5, 6
- acute respiratory syndrome and adaptive mutation: 1, 2, 3, 4, 5
- acute respiratory syndrome and adaptive potential: 1, 2, 3, 4, 5, 6, 7
- adaptive mutation and additional adaptive mutation: 1, 2, 3
Co phrase search for related documents, hyperlinks ordered by date