Author: Cinatl Jr., J.; Hoever, G.; Morgenstern, B.; Preiser, W.; Vogel, J.-U.; Hofmann, W.-K.; Bauer, G.; Michaelis, M.; Rabenau, H. F.; Doerr, H. W.
Title: Infection of cultured intestinal epithelial cells with severe acute respiratory syndrome coronavirus Cord-id: 9k8zseao Document date: 2004_1_1
ID: 9k8zseao
Snippet: To identify a model for the study of intestinal pathogenesis of severe acute respiratory syndrome (SARS) we tested the sensitivity of six human intestinal epithelial cell lines to infection with SARS coronavirus (SARS-CoV). In permissive cell lines, effects of SARS-CoV on cellular gene expression were analysed using high-density oligonucleotide arrays. Caco-2 and CL-14 cell lines were found to be highly permissive to SARS-CoV, due to the presence of angiotensin-converting enzyme 2 as a functiona
Document: To identify a model for the study of intestinal pathogenesis of severe acute respiratory syndrome (SARS) we tested the sensitivity of six human intestinal epithelial cell lines to infection with SARS coronavirus (SARS-CoV). In permissive cell lines, effects of SARS-CoV on cellular gene expression were analysed using high-density oligonucleotide arrays. Caco-2 and CL-14 cell lines were found to be highly permissive to SARS-CoV, due to the presence of angiotensin-converting enzyme 2 as a functional receptor. In both cell lines, SARS-CoV infection deregulated expression of cellular genes which may be important for the intestinal pathogenesis of SARS.
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