Author: Linlin Zhang; Daizong Lin; Yuri Kusov; Yong Nian; Qingjun Ma; Jiang Wang; Albrecht von Brunn; Pieter Leyssen; Kristina Lanko; Johan Neyts; Adriaan de Wilde; Eric J. Snijder; Hong Liu; Rolf Hilgenfeld
Title: Alpha-ketoamides as broad-spectrum inhibitors of coronavirus and enterovirus replication Document date: 2020_2_10
ID: 7n8p9okf_51
Snippet: This work demonstrates the power of structure-based approaches in the design of broad-spectrum antiviral compounds with roughly equipotent activity against coronaviruses and enteroviruses. We observed a good correlation between the inhibitory activity of the designed compounds against the isolated proteases, in viral replicons, and in virus-infected Huh7 cells. One of the compounds (11r) exhibits excellent anti-MERS-CoV activity in virus-infected.....
Document: This work demonstrates the power of structure-based approaches in the design of broad-spectrum antiviral compounds with roughly equipotent activity against coronaviruses and enteroviruses. We observed a good correlation between the inhibitory activity of the designed compounds against the isolated proteases, in viral replicons, and in virus-infected Huh7 cells. One of the compounds (11r) exhibits excellent anti-MERS-CoV activity in virus-infected Huh7 cells. Because of the high similarity between the main proteases of SARS-CoV and the novel BetaCoV/Wuhan/2019, we expect 11r to exhibit good antiviral activity against the new coronavirus as well.
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