A computational analysis on Covid-19 transmission raises imuuno-epidemiology concerns.

Kyriakopoulos, A.; Zhao, S.

For Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-COV-2) the investigation of the heterogeneity of individual infectiousness becomes important due to the cross reactive immunity of general population. Using a sample of infected population with SARS-COV-2 in close geographical proximity to the initial Severe Advanced Respiratory Syndrome-1 [SARS-1] outbreak, we explored the association between infectors age and dispersion (or heterogeneity) of individual infectiousness (k) in order to investigate the relatedness with the age of an individuals capability to disperse SARS-COV-2. Interestingly, we find a negative association between k and increase of infectors age. Significantly this becomes more evident for the age group of 20-60 years comparing with the infectors with younger age. This raises important immuno-epidemiology concerns for effectiveness of public health measures to contain the disease.