Selected article for: "binding affinity and high affinity"
Author: Katie M. Campbell; Gabriela Steiner; Daniel K. Wells; Antoni Ribas; Anusha Kalbasi
Title: Prediction of SARS-CoV-2 epitopes across 9360 HLA class I alleles
  • Document date: 2020_4_1
    • ID: bj454swk_6
    Snippet: We deployed peptide binding predictions across 9-mer peptides derived from 1,075 protein sequences spanning 166 SARS-CoV-2 genotypes for 9,360 class I HLA alleles (2,987 HLA-A; 3,707 HLA-B; 2,666 HLA-C). Peptide binding predictions were filtered to those with a high-binding affinity (<500nM) to identify putative class I HLA antigens ( Figure 1A ). There were 6,748 unique combinations of peptides and HLA alleles (pMHCs) with a predicted binding af.....
    Document: We deployed peptide binding predictions across 9-mer peptides derived from 1,075 protein sequences spanning 166 SARS-CoV-2 genotypes for 9,360 class I HLA alleles (2,987 HLA-A; 3,707 HLA-B; 2,666 HLA-C). Peptide binding predictions were filtered to those with a high-binding affinity (<500nM) to identify putative class I HLA antigens ( Figure 1A ). There were 6,748 unique combinations of peptides and HLA alleles (pMHCs) with a predicted binding affinity of less than 500nM (Supplementary Table 3) , including 1,103 unique peptides and 1,022 HLA alleles (295 HLA-A, 614 HLA-B, and 113 HLA-C).

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