Selected article for: "new method and protein protein"
Author: Siminea, Nicoleta; Popescu, Victor; Martin, Jose Angel Sanchez; Florea, Daniela; Gavril, Georgiana; Gheorghe, Ana-Maria; Itcus, Corina; Kanhaiya, Krishna; Pacioglu, Octavian; Popa, Laura Ioana; Trandafir, Romica; Tusa, Maria Iris; Sidoroff, Manuela; Paun, Mihaela; Czeizler, Eugen; Paun, Andrei; Petre, Ion
Title: Network analytics for drug repurposing in COVID-19
  • Cord-id: 9trmpbfk
  • Document date: 2021_6_23
    • ID: 9trmpbfk
    Snippet: To better understand the potential of drug repurposing in COVID-19, we analyzed control strategies over essential host factors for SARS-CoV-2 infection. We constructed comprehensive directed protein-protein interaction networks integrating the top ranked host factors, drug target proteins, and directed protein-protein interaction data. We analyzed the networks to identify drug targets and combinations thereof that offer efficient control over the host factors. We validated our findings against c
    Document: To better understand the potential of drug repurposing in COVID-19, we analyzed control strategies over essential host factors for SARS-CoV-2 infection. We constructed comprehensive directed protein-protein interaction networks integrating the top ranked host factors, drug target proteins, and directed protein-protein interaction data. We analyzed the networks to identify drug targets and combinations thereof that offer efficient control over the host factors. We validated our findings against clinical studies data and bioinformatics studies. Our method offers a new insight into the molecular details of the disease and into potentially new therapy targets for it. Our approach for drug repurposing is significant beyond COVID-19 and may be applied also to other diseases.

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