Author: Giuseppe Gritti; Federico Raimondi; Diego Ripamonti; Ivano Riva; Francesco Landi; Leonardo Alborghetti; Marco Frigeni; Marianna Damiani; Caterina Micò; Stefano Fagiuoli; Roberto Cosentini; Ferdinando Luca Lorini; Fabrizio Fabretti; Jonathan Morgan; Benjamin M.J. Owens; Karan Kanhai; Jim Cowburn; Marco Rizzi; Fabiano Di Marco; Alessandro Rambaldi
Title: Use of siltuximab in patients with COVID-19 pneumonia requiring ventilatory support Document date: 2020_4_3
ID: ajurlkwr_4
Snippet: SARS-CoV and the Middle East respiratory syndrome CoV (MERS-CoV) are highly pathogenic coronaviruses that infect the lower respiratory tract causing severe pneumonia that results in rapid viral replication, massive inflammatory cell infiltration and elevated pro-inflammatory cytokine levels including Interleukin-6 (IL-6) and Creactive protein (CRP) that lead to severe respiratory failure, which can be described as acute respiratory distress syndr.....
Document: SARS-CoV and the Middle East respiratory syndrome CoV (MERS-CoV) are highly pathogenic coronaviruses that infect the lower respiratory tract causing severe pneumonia that results in rapid viral replication, massive inflammatory cell infiltration and elevated pro-inflammatory cytokine levels including Interleukin-6 (IL-6) and Creactive protein (CRP) that lead to severe respiratory failure, which can be described as acute respiratory distress syndrome (ARDS) (Channappanavar R and Perlman S. 2017). The SARS-CoV-2 virus has also been suggested to initiate a cytokine storm in patients with COVID-19 (Mehta P et al. 2020) . IL-6 blockade has been identified as a potential strategy to mitigate the complications associated with COVID-19 infection.
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