Author: Lee, Jeong Seok; Park, Seongwan; Jeong, Hye Won; Ahn, Jin Young; Choi, Seong Jin; Lee, Hoyoung; Choi, Baekgyu; Nam, Su Kyung; Sa, Moa; Kwon, Ji-Soo; Jeong, Su Jin; Lee, Heung Kyu; Park, Sung Ho; Park, Su-Hyung; Choi, Jun Yong; Kim, Sung-Han; Jung, Inkyung; Shin, Eui-Cheol
Title: Immunophenotyping of COVID-19 and influenza highlights the role of type I interferons in development of severe COVID-19 Cord-id: bqvn3ceq Document date: 2020_7_10
ID: bqvn3ceq
Snippet: Although most SARS-CoV-2-infected individuals experience mild coronavirus disease 2019 (COVID-19), some patients suffer from severe COVID-19, which is accompanied by acute respiratory distress syndrome and systemic inflammation. To identify factors driving severe progression of COVID-19, we performed single-cell RNA-seq using peripheral blood mononuclear cells (PBMCs) obtained from healthy donors, patients with mild or severe COVID-19, and patients with severe influenza. Patients with COVID-19 e
Document: Although most SARS-CoV-2-infected individuals experience mild coronavirus disease 2019 (COVID-19), some patients suffer from severe COVID-19, which is accompanied by acute respiratory distress syndrome and systemic inflammation. To identify factors driving severe progression of COVID-19, we performed single-cell RNA-seq using peripheral blood mononuclear cells (PBMCs) obtained from healthy donors, patients with mild or severe COVID-19, and patients with severe influenza. Patients with COVID-19 exhibited hyper-inflammatory signatures across all types of cells among PBMCs, particularly up-regulation of the TNF/IL-1β-driven inflammatory response as compared to severe influenza. In classical monocytes from patients with severe COVID-19, type I IFN response co-existed with the TNF/IL-1β-driven inflammation, and this was not seen in patients with milder COVID-19. Interestingly, we documented type I IFN-driven inflammatory features in patients with severe influenza as well. Based on this, we propose that the type I IFN response plays a pivotal role in exacerbating inflammation in severe COVID-19.
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