Selected article for: "amino acid and mammalian gene"
Author: Phillip Davis; John Bagnoli; David Yarmosh; Alan Shteyman; Lance Presser; Sharon Altmann; Shelton Bradrick; Joseph A. Russell
Title: Vorpal: A novel RNA virus feature-extraction algorithm demonstrated through interpretable genotype-to-phenotype linear models
  • Document date: 2020_3_2
    • ID: 48mtdwuv_24
    Snippet: The highest coefficient predictor in the model for Influenza A segment 1, which codes for the 303 PB2 polymerase gene, is a motif which represents a mammalian amino acid substitution 304 experimentally observed in a mouse model 24 . This mammalian adaptation was identified as 305 relevant to the temperature sensitivity of the polymerase in H5N1. The reversion of the avian 306 conformation containing the glutamic acid residue, to the mammalian con.....
    Document: The highest coefficient predictor in the model for Influenza A segment 1, which codes for the 303 PB2 polymerase gene, is a motif which represents a mammalian amino acid substitution 304 experimentally observed in a mouse model 24 . This mammalian adaptation was identified as 305 relevant to the temperature sensitivity of the polymerase in H5N1. The reversion of the avian 306 conformation containing the glutamic acid residue, to the mammalian conformation containing 307 offers another angle for interpretation, especially in regards to identifying possible spill-over or 353

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