Selected article for: "amino acid and Genbank accession"
Author: Zehua Zeng; Zhi Luo; Hongwu Du
Title: Predictions for the binding domain and potential new drug targets of 2019-nCoV
  • Document date: 2020_3_2
    • ID: fvig79k3_3
    Snippet: According to the evolutionary analysis of coronavirus, 2019-nCov is probably originated from bat, and the Sprotein of 2019-nCoV may enter human cells by interacting with human ACE2 receptor, which revealed the pathopoeia mechanism of 2019-nCoV 1 . On the other hand, 2019-nCoV shares about 96.2% sequence identity to BatCoV RATG13 2 . By comparing the amino acid sequence of 2019-nCoV S-protein (GenBank Accession: MN908947.3) with Bat SARS-like coro.....
    Document: According to the evolutionary analysis of coronavirus, 2019-nCov is probably originated from bat, and the Sprotein of 2019-nCoV may enter human cells by interacting with human ACE2 receptor, which revealed the pathopoeia mechanism of 2019-nCoV 1 . On the other hand, 2019-nCoV shares about 96.2% sequence identity to BatCoV RATG13 2 . By comparing the amino acid sequence of 2019-nCoV S-protein (GenBank Accession: MN908947.3) with Bat SARS-like coronavirus isolate bat-SL-CoVZC45 and Bat SARS-like coronavirus isolate Bat-SL-CoVZXC21, the latter two were shown to share 89.1% and 88.6% sequence identity to 2019-nCoV S-protein (supplementary figure 1) . Thus, the hypothesis that 2019-nCoV may share the same pathway with Bat SARS-like coronavirus.

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